Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 7/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510314 | 0.94 | NOTUM (0.35) | NOTUMCTSKABL1MAPK1PKM | |
| SCHEMBL210181 | 0.92 | MAP4K1 (0.38) | MAPK1RAB9AMAP3K5MAPT | |
| SCHEMBL210182 | 0.92 | MAP4K1 (0.38) | MAPK1RAB9AMAP3K5MAPT | |
| SCHEMBL212522 | 0.92 | MAPK1 (0.33) | NOTUMCTSKABL1MAPK1PKM | |
| SCHEMBL210472 | 0.90 | NOTUM (0.34) | NOTUMCTSKABL1MAPK1PKM | |
| SCHEMBL27789219 | 0.90 | CTSK (0.40) | NOTUMCTSKABL1MAPK1PKM | |
| SCHEMBL27810814 | 0.90 | CTSK (0.40) | NOTUMCTSKABL1MAPK1PKM | |
| SCHEMBL2726878 | 0.90 | ANO1 (0.33) | NOTUMCTSKABL1MAPK1PKM | |
| SCHEMBL213602 | 0.90 | ABL1 (0.33) | NOTUMCTSKABL1MAPK1PKM | |
| SCHEMBL213601 | 0.90 | ABL1 (0.33) | NOTUMCTSKABL1MAPK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |