Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 13/20 | 0.50 |
| ▸ | MMP1 | P03956 | 8/20 | 0.50 |
| ▸ | MMP3 | P08254 | 8/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8100368 | 0.93 | CSNK1E (0.60) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL8094019 | 0.93 | CSNK1E (0.60) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL8095039 | 0.93 | CSNK1E (0.60) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL8094331 | 0.93 | CSNK1E (0.60) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL8094075 | 0.93 | CSNK1E (0.60) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL8093074 | 0.93 | CSNK1E (0.60) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL8093624 | 0.93 | CSNK1E (0.60) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL8093653 | 0.91 | CSNK1E (0.57) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL30903825 | 0.89 | CSNK1E (0.60) | CSNK1ECNR2MMP2MMP1MMP3 | |
| SCHEMBL22806767 | 0.89 | CSNK1E (0.60) | CSNK1ECNR2MMP2MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111362799-B | Preparation method of long-chain diacid monobenzyl ester compound | 天津法莫西医药科技有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-111362799-A | Preparation method of long-chain diacid monobenzyl ester compound | 天津法莫西医药科技有限公司 | 2020-07-03 | — | — | CN | disclosed |