Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.67 |
| ▸ | FLT3 | P36888 | 3/20 | 0.67 |
| ▸ | ROS1 | P08922 | 5/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28435534 | 0.91 | ALK (0.78) | ALKFLT3ROS1EGFRAXL | |
| SCHEMBL28430819 | 0.90 | ALK (0.70) | ALKFLT3ROS1EGFRAXL | |
| SCHEMBL28442130 | 0.89 | ALK (0.72) | ALKFLT3EGFRPTK2 | |
| SCHEMBL28430784 | 0.88 | ALK (0.85) | ALKFLT3ROS1EGFR | |
| SCHEMBL28441578 | 0.84 | ALK (0.78) | ALKFLT3ROS1EGFRMAP3K7 | |
| SCHEMBL28430807 | 0.83 | ALK (0.84) | ALKFLT3ROS1EGFRPTK2 | |
| SCHEMBL28434966 | 0.80 | ALK (0.98) | ALKFLT3ROS1EGFRAXL | |
| SCHEMBL28438911 | 0.80 | ALK (1.00) | ALKFLT3ROS1EGFRAXL | |
| SCHEMBL28435828 | 0.79 | ALK (1.00) | ALKFLT3ROS1EGFRAXL | |
| SCHEMBL28434599 | 0.79 | ALK (0.89) | ALKFLT3ROS1EGFRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111484484-B | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2021-11-23 | — | — | CN | claimed |
| CN-111484484-A | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2020-08-04 | — | — | CN | claimed |
| CN-111484484-B | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2021-11-23 | — | — | CN | disclosed |
| CN-111484484-A | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2020-08-04 | — | — | CN | disclosed |