Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 12/20 | 0.48 |
| ▸ | HTR1B | P28222 | 12/20 | 0.48 |
| ▸ | QDPR | P09417 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21967952 | 0.86 | HTR1D (0.55) | MAPTLMNAMEN1KMT2AHTR1D | |
| SCHEMBL20557557 | 0.85 | MEN1 (0.47) | MAPTLMNAMEN1KMT2AHTR1D | |
| SCHEMBL29555690 | 0.85 | MEN1 (0.47) | MAPTLMNAMEN1KMT2AHTR1D | |
| SCHEMBL30552379 | 0.85 | GABRP (0.54) | MAPTLMNAMEN1KMT2AHTR1D | |
| SCHEMBL5950691 | 0.85 | GABRP (0.54) | MAPTLMNAMEN1KMT2AHTR1D | |
| SCHEMBL28725598 | 0.83 | HTR1D (0.56) | KMT2AHTR1DHTR1B | |
| SCHEMBL28725580 | 0.82 | HTR1D (0.52) | MAPTLMNAMEN1KMT2AHTR1D | |
| SCHEMBL25223587 | 0.81 | HTR1D (0.51) | MAPTLMNAMEN1KMT2AHTR1D | |
| SCHEMBL28725616 | 0.81 | HTR1D (0.59) | HTR1DHTR1B | |
| SCHEMBL28725694 | 0.79 | MAPT (0.47) | MAPTLMNAMEN1KMT2AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111448190-B | Substituted indole compounds | 百时美施贵宝公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-109715617-B | Dimethoxyphenyl-substituted indole compounds as inhibitors of TLR7, TLR8 or TLR9 | 百时美施贵宝公司 | 2022-04-19 | — | — | CN | disclosed |
| CN-111448190-A | Substituted indole compounds | 百时美施贵宝公司 | 2020-07-24 | — | — | CN | disclosed |