Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28434573 | 0.88 | JAK2 (0.67) | JAK2FLT3 | |
| SCHEMBL28439364 | 0.87 | JAK2 (0.54) | JAK2FLT3 | |
| SCHEMBL28896995 | 0.86 | JAK2 (0.57) | JAK2FLT3 | |
| SCHEMBL28434556 | 0.86 | TAAR1 (0.53) | — | |
| SCHEMBL28440889 | 0.85 | JAK2 (0.68) | JAK2FLT3 | |
| SCHEMBL28442728 | 0.85 | JAK2 (0.67) | JAK2FLT3 | |
| SCHEMBL28447921 | 0.84 | JAK2 (0.53) | JAK2FLT3 | |
| SCHEMBL28451446 | 0.84 | JAK2 (0.53) | JAK2FLT3 | |
| SCHEMBL28442019 | 0.84 | — | — | |
| SCHEMBL28441102 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | claimed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |