Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28438103 | 0.86 | PRMT5 (0.59) | PRMT5WDR77 | |
| SCHEMBL20721584 | 0.80 | PRMT5 (0.52) | PRMT5WDR77CLK1CLK2DYRK1A | |
| SCHEMBL29391785 | 0.80 | PRMT5 (0.52) | PRMT5WDR77CLK1CLK2DYRK1A | |
| SCHEMBL20721580 | 0.76 | PRMT5 (0.73) | PRMT5WDR77 | |
| SCHEMBL29391889 | 0.76 | PRMT5 (0.73) | PRMT5WDR77 | |
| SCHEMBL28442864 | 0.70 | PRMT5 (0.48) | PRMT5WDR77 | |
| SCHEMBL22522086 | 0.68 | PRMT5 (0.45) | PRMT5WDR77CLK4HSP90AA1HSP90AB1 | |
| SCHEMBL21061562 | 0.66 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL20721514 | 0.65 | PRMT5 (0.72) | PRMT5WDR77 | |
| SCHEMBL20721601 | 0.65 | PRMT5 (0.58) | PRMT5WDR77HSP90AA1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527099-A | Selective inhibitors of protein arginine methyltransferase 5(PRMT5) | 普莱鲁德疗法有限公司 | 2020-08-11 | — | — | CN | disclosed |