SCHEMBL28440528

SCHEMBL28440528

CC1=C(C(=O)O)C(c2ccc(Cl)c(Cl)c2)C(C(=O)OCCC#N)=C(C)N1

nearest known ligand 0.55

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CACNA1B Q00975 15/20 0.52
ABCC1 P33527 1/20 0.48
CACNA1F O60840 2/20 0.46
CACNA1D Q01668 2/20 0.46
CACNA1S Q13698 2/20 0.46
CACNA1C Q13936 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28440527 0.96 ABCC1 (0.52) CACNA1BABCC1CACNA1FCACNA1DCACNA1S
SCHEMBL28441003 0.92 CACNA1F (0.53) ABCC1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL5856384 0.86 CACNA1B (0.62) CACNA1BCACNA1C
SCHEMBL5856387 0.86 CACNA1B (0.62) CACNA1BCACNA1C
SCHEMBL5855026 0.86 CACNA1B (0.70) CACNA1B
SCHEMBL27541938 0.83 CACNA1B (0.55) CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL27515732 0.83 CACNA1B (0.67) CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL27520042 0.81 CACNA1B (0.52) CACNA1BABCC1CACNA1FCACNA1DCACNA1S
SCHEMBL5855031 0.81 CACNA1B (0.63) CACNA1BABCC1CACNA1FCACNA1DCACNA1S
SCHEMBL27536070 0.81 CACNA1F (0.59) CACNA1BCACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111423362-A Preparation method of two high-purity clevidipine butyrate impurities 山东省药学科学院 2020-07-17 CN claimed
CN-111423362-A Preparation method of two high-purity clevidipine butyrate impurities 山东省药学科学院 2020-07-17 CN disclosed