SCHEMBL28441003

SCHEMBL28441003

COC(=O)C1=C(C)NC(C)=C(C(=O)OCCC#N)C1c1ccc(Cl)c(Cl)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 4/20 0.53
CACNA1D Q01668 4/20 0.53
CACNA1S Q13698 4/20 0.53
CACNA1C Q13936 4/20 0.53
ADORA3 P0DMS8 3/20 0.49
ABCC1 P33527 1/20 0.48
ADRA1A P35348 2/20 0.48
ADRA2A P08913 1/20 0.48
ADRA2B P18089 1/20 0.48
ADRA2C P18825 1/20 0.48
ADRA1D P25100 1/20 0.48
ADRA1B P35368 1/20 0.48
KMT2A Q03164 5/20 0.47
CYP2C9 P11712 6/20 0.47
CYP3A4 P08684 5/20 0.47
CYP2C19 P33261 5/20 0.47
HIF1A Q16665 5/20 0.47
MEN1 O00255 4/20 0.47
CYP1A2 P05177 4/20 0.47
MAPT P10636 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28440527 0.96 ABCC1 (0.52) CACNA1FCACNA1DCACNA1SCACNA1CABCC1
SCHEMBL28440528 0.92 CACNA1B (0.52) CACNA1FCACNA1DCACNA1SCACNA1CABCC1
SCHEMBL28435076 0.85 ADORA3 (0.67) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL3035270 0.85 TSHR (0.59) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL5856387 0.85 CACNA1B (0.62) CACNA1CADORA3KMT2AMEN1NR1I2
SCHEMBL5856384 0.85 CACNA1B (0.62) CACNA1CADORA3KMT2AMEN1NR1I2
SCHEMBL9269230 0.84 CACNA1F (0.67) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL31059899 0.83 ADORA3 (0.71) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL31059900 0.83 ADORA3 (0.71) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL28443306 0.82 CYP2C9 (0.53) CACNA1FCACNA1DCACNA1SCACNA1CADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111423362-A Preparation method of two high-purity clevidipine butyrate impurities 山东省药学科学院 2020-07-17 CN disclosed