Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28438196 | 0.86 | PRMT5 (0.44) | PRMT5WDR77 | |
| SCHEMBL20721420 | 0.82 | PRMT5 (0.43) | PRMT5WDR77CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL28439637 | 0.81 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL21682243 | 0.77 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL28442864 | 0.74 | PRMT5 (0.48) | PRMT5WDR77 | |
| SCHEMBL21682198 | 0.71 | PRMT5 (0.63) | PRMT5WDR77 | |
| SCHEMBL20721464 | 0.68 | PRMT5 (0.49) | PRMT5WDR77 | |
| SCHEMBL29392351 | 0.68 | PRMT5 (0.49) | PRMT5WDR77 | |
| SCHEMBL18571918 | 0.67 | PRMT5 (0.42) | PRMT5WDR77 | |
| SCHEMBL20721605 | 0.67 | PRMT5 (0.54) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527099-A | Selective inhibitors of protein arginine methyltransferase 5(PRMT5) | 普莱鲁德疗法有限公司 | 2020-08-11 | — | — | CN | disclosed |