Meglutol

Meglutol

SCHEMBL28443

CC(O)(CC(=O)O)CC(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 1.00
CHRM1 P11229 1/20 1.00
TBXA2R P21731 1/20 1.00
ADRA1A P35348 1/20 1.00
TSHR P16473 3/20 0.55
CYP2C19 P33261 2/20 0.55
HIF1A Q16665 2/20 0.55
CYP2D6 P10635 1/20 0.55
ALDH1A1 P00352 2/20 0.50
CPT2 P23786 2/20 0.48
KDM4E B2RXH2 1/20 0.48
FFAR1 O14842 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
ACLY P53396 3/20 0.40
FFAR3 O14843 1/20 0.39
TET2 Q6N021 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Meglutol SCHEMBL8718194 1.00 HMGCR (1.00) HMGCRCHRM1TBXA2RADRA1ATSHR
Meglutol SCHEMBL31372614 0.89 HMGCR (0.79) HMGCRCHRM1TBXA2RADRA1ATSHR
SCHEMBL16005836 0.89 HMGCR (0.79) HMGCRCHRM1TBXA2RADRA1ATSHR
SCHEMBL9907217 0.89 HMGCR (0.79) HMGCRCHRM1TBXA2RADRA1ATSHR
SCHEMBL17227383 0.87 HMGCR (0.75) HMGCRCHRM1TBXA2RADRA1ATSHR
SCHEMBL15693959 0.87 HMGCR (0.75) HMGCRCHRM1TBXA2RADRA1ATSHR
SCHEMBL16882363 0.87 HMGCR (0.75) HMGCRCHRM1TBXA2RADRA1ATSHR
SCHEMBL126376 0.87 HMGCR (0.75) HMGCRCHRM1TBXA2RADRA1ATSHR
Meglutol SCHEMBL30976339 0.87 HMGCR (0.75) HMGCRCHRM1TBXA2RADRA1ATSHR
SCHEMBL16603051 0.87 HMGCR (0.75) HMGCRCHRM1TBXA2RADRA1ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2978 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250270596-A1 MEVALONATE DERIVATIVES AND METHODS FOR MAKING THE SAME UNIV DUKE (US) 2025-08-28 US claimed
CN-120157725-A Meglutol derivatives, preparation method, pharmaceutical composition and application thereof 中国医学科学院药物研究所 2025-06-17 CN claimed
US-20250129385-A1 GENE-EDITING METHODS FOR EMBRYONIC STEM CELLS ABS GLOBAL, INC. (US) 2025-04-24 US claimed
EP-4537111-A2 MULTI-OMICS ASSESSMENT Prognomiq Inc (US) 2025-04-16 EP claimed
CN-119816897-A Multiple study assessment 普罗科技有限公司 2025-04-11 CN claimed
WO-2025072741-A1 PRESERVATIVES FOR MOLECULAR SAMPLE ANALYSIS WITH SAMPLE COLLECTION DEVICES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-04-03 WO claimed
US-20250051852-A1 BIOMARKERS TO DETECT AGGRESSIVE PROSTATE CANCER FROM INDOLENT FORMS AND TREATMENT THEREOF THE JOHNS HOPKINS UNIVERSITY (US) 2025-02-13 US claimed
US-20250043306-A1 GENE-EDITING METHODS FOR GENETIC IMPROVEMENT IN LIVESTOCK ABS GLOBAL, INC. (US) 2025-02-06 US claimed
US-20250027120-A1 ACID-RESISTANT YEAST STRAIN FOR EFFICIENT PRODUCTION OF SUCCINIC ACID, AND CONSTRUCTION METHOD THEREFOR AND USE THEREOF TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES (CN) 2025-01-23 US claimed
WO-2025018330-A1 CONCENTRATED COMPOSITION FOR SOIL IMPROVEMENT 花王株式会社 2025-01-23 WO claimed
EP-0273202-A2 Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. Van Scott, Eugene J., Dr. (US) 1988-07-06 EP claimed
EP-0148666-B1 PROCESS FOR PREPARING HYDROXY-3-METHYL-3 GLUTARIC ACID SANOFI (FR) 1987-05-20 EP claimed
US-4640750-A Process for the preparation of 3-hydroxy-3-methylglutaric acid HOECHST AKTIENGESELLSCHAFT (DE) 1987-02-03 US claimed
EP-0178106-A2 Enzymatic process NOVO NORDISK A/S (DK) 1986-04-16 EP claimed
US-4546203-A ONE-STEP OXIDATION OF 3-METHYL-1,3,5-PENTANETRIOL BY AN ALKALI PERMANGANATE IN AQUEOUS MEDIA AMERICAN HOECHST CORPORATION (US) 1985-10-08 US claimed
EP-0082344-B1 PROCESS FOR PREPARING BETA-HYDROXY-BETA-METHYLGLUTARIC ACID AMERICAN HOECHST CORPORATION (US) 1985-09-18 EP claimed
EP-0097578-B1 PROCESS FOR THE PREPARATION OF 3-METHYL-3-HYDROXYGLUTARIC ACID AND AN INTERMEDIATE PRODUCT FOR THE PREPARATION THEREOF ROUSSEL-UCLAF (FR) 1985-09-11 EP claimed
US-4467108-A Process for the preparation of 3-methyl-3-hydroxy-glutaric acid ROUSSEL UCLAF (FR) 1984-08-21 US claimed
EP-0082344-A1 Process for preparing beta-hydroxy-beta-methylglutaric acid AMERICAN HOECHST CORPORATION (US) 1983-06-29 EP claimed
US-4105794-A 3-HYDROXY-3-METHYLGLUTARIC ACID OR SALT THEREOF CALBIOCHEM-BEHRING CORP. (US) 1978-08-08 US claimed