Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28443110 | 1.00 | DPP4 (0.36) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28438584 | 0.93 | MMP2 (0.34) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28440538 | 0.93 | MMP2 (0.34) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28440540 | 0.93 | MMP2 (0.34) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28438585 | 0.93 | MMP2 (0.34) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28438597 | 0.91 | CYP3A4 (0.35) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28439310 | 0.91 | CYP3A4 (0.34) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28443701 | 0.91 | CYP3A4 (0.35) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28438596 | 0.91 | CYP3A4 (0.35) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28439311 | 0.91 | CYP3A4 (0.34) | DPP4DPP7CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111386261-A | Coumarin derivatives, preparation method thereof and application thereof in cancer treatment | 利德发现中心有限责任公司 | 2020-07-07 | — | — | CN | claimed |
| CN-111386261-A | Coumarin derivatives, preparation method thereof and application thereof in cancer treatment | 利德发现中心有限责任公司 | 2020-07-07 | — | — | CN | disclosed |