Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28443651 | 0.90 | JAK2 (0.56) | JAK2FLT3TAAR1 | |
| SCHEMBL28435360 | 0.89 | JAK2 (0.56) | JAK2FLT3 | |
| SCHEMBL28443646 | 0.86 | JAK2 (0.53) | JAK2FLT3 | |
| SCHEMBL28897516 | 0.86 | PTK2 (0.60) | PTK2JAK3 | |
| SCHEMBL28442728 | 0.83 | JAK2 (0.67) | JAK2FLT3SLC6A3TAAR1 | |
| SCHEMBL24426180 | 0.82 | JAK2 (0.77) | JAK2FLT3PTK2JAK3 | |
| SCHEMBL28442566 | 0.82 | PIK3R1 (0.53) | JAK2FLT3TAAR1 | |
| SCHEMBL28442721 | 0.80 | FGFR4 (0.58) | SLC6A3KCNH2TAAR1 | |
| SCHEMBL28439357 | 0.80 | JAK2 (0.51) | JAK2FLT3 | |
| SCHEMBL28445183 | 0.80 | TAAR1 (0.54) | JAK2FLT3SLC6A3KCNH2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |