Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.77 |
| ▸ | FLT3 | P36888 | 8/20 | 0.77 |
| ▸ | JAK3 | P52333 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.52 |
| ▸ | MERTK | Q12866 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28443297 | 0.88 | JAK2 (0.60) | JAK2FLT3JAK3LRRK2 | |
| SCHEMBL22860801 | 0.88 | JAK2 (0.82) | JAK2FLT3JAK3ALDH1A1POLB | |
| SCHEMBL24426171 | 0.87 | JAK2 (0.81) | JAK2FLT3JAK3ALDH1A1POLB | |
| SCHEMBL28443644 | 0.84 | JAK2 (0.76) | JAK2FLT3JAK3ALDH1A1POLB | |
| SCHEMBL28897515 | 0.84 | JAK3 (0.62) | JAK2FLT3JAK3AXLSYK | |
| SCHEMBL28443296 | 0.82 | JAK2 (0.54) | JAK2FLT3JAK3PTK2 | |
| SCHEMBL24426212 | 0.81 | JAK2 (1.00) | JAK2FLT3JAK3ALDH1A1POLB | |
| SCHEMBL29236036 | 0.81 | JAK2 (0.70) | JAK2FLT3JAK3ALDH1A1POLB | |
| SCHEMBL29235901 | 0.80 | JAK2 (0.85) | JAK2FLT3JAK3ALDH1A1POLB | |
| SCHEMBL30135476 | 0.80 | JAK3 (0.65) | JAK2FLT3JAK3AXLSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113891881-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2022-01-04 | — | — | CN | claimed |
| EP-3998254-A1 | 2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREOF | Shenyang Pharmaceutical University (CN) | 2022-05-18 | — | — | EP | disclosed |
| EP-3998254-A1 | 2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREOF | Shenyang Pharmaceutical University (CN) | 2022-05-18 | — | — | EP | disclosed |
| CN-113891881-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2022-01-04 | — | — | CN | disclosed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |