Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 5/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.49 |
| ▸ | MTOR | P42345 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896923 | 0.95 | PIK3CA (0.47) | PIK3R1PIK3CAMTORJAK2FLT3 | |
| SCHEMBL24426189 | 0.88 | JAK2 (0.59) | PIK3R1PIK3CAMTORJAK2FLT3 | |
| SCHEMBL28440872 | 0.85 | JAK2 (0.48) | PIK3R1PIK3CAMTORJAK2FLT3 | |
| SCHEMBL28443652 | 0.85 | JAK2 (0.64) | PIK3R1PIK3CAMTORJAK2FLT3 | |
| SCHEMBL28679840 | 0.83 | JAK2 (0.57) | PIK3R1PIK3CAMTORJAK2FLT3 | |
| SCHEMBL29670019 | 0.83 | JAK2 (0.57) | PIK3R1PIK3CAMTORJAK2FLT3 | |
| SCHEMBL28434570 | 0.81 | JAK2 (0.51) | PIK3R1PIK3CAMTORJAK2FLT3 | |
| SCHEMBL28442707 | 0.79 | JAK2 (0.49) | JAK2FLT3JAK3ALDH1A1MAPK9 | |
| SCHEMBL28434562 | 0.79 | JAK2 (0.52) | JAK2FLT3JAK3ALDH1A1MAPK9 | |
| SCHEMBL28451619 | 0.75 | MAPK9 (0.48) | MTORJAK2JAK3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | claimed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |