Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 7/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28435371 | 0.88 | LGMN (0.49) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL28441103 | 0.87 | MAPK9 (0.47) | MAPK9MAPK10PIK3CDPIK3C2BMTOR | |
| SCHEMBL28440872 | 0.84 | JAK2 (0.48) | MAPK9MAPK10MTORMEN1KMT2A | |
| SCHEMBL28451613 | 0.84 | JAK2 (0.59) | MAPK9MAPK10MAPK8JAK2JAK1 | |
| SCHEMBL28445178 | 0.80 | ALDH1A1 (0.41) | MAPK9MAPK10PIK3CDPIK3C2BMTOR | |
| SCHEMBL28443652 | 0.77 | JAK2 (0.64) | MTORLMNAPOLBJAK2JAK3 | |
| SCHEMBL28442021 | 0.76 | POLB (0.45) | MAPK9MAPK10PIK3CDPIK3C2BMTOR | |
| SCHEMBL28442722 | 0.75 | FGFR4 (0.71) | MAPK9MAPK10JAK2JAK1TYK2 | |
| SCHEMBL29670005 | 0.75 | JAK2 (0.60) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL28897517 | 0.73 | LRRK2 (0.53) | MAPK9MAPK10LMNAJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |