Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.60 |
| ▸ | FLT1 | P17948 | 5/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.60 |
| ▸ | RET | P07949 | 8/20 | 0.55 |
| ▸ | KIF5B | P33176 | 8/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28445421 | 0.91 | KDR (0.73) | KDRRETKIF5BEGFR | |
| SCHEMBL28436953 | 0.88 | KDR (0.57) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL29428183 | 0.88 | KDR (0.57) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL28451851 | 0.85 | KDR (0.73) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL28447259 | 0.82 | KDR (0.67) | KDRFLT1RETEGFR | |
| SCHEMBL28439580 | 0.81 | EGFR (0.71) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL16760558 | 0.80 | RET (0.77) | KDRRETKIF5B | |
| SCHEMBL28444206 | 0.80 | EGFR (0.71) | KDRFLT1RETEGFREPHB2 | |
| SCHEMBL29428176 | 0.80 | KDR (0.60) | KDRFLT1FGFR1RETKIF5B | |
| SCHEMBL28897563 | 0.79 | KDR (0.73) | KDRFLT1FGFR1RETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499583-B | Quinazoline derivative and application thereof as antitumor drug | 沈阳工业大学 | 2022-02-15 | — | — | CN | disclosed |
| CN-111499583-A | Quinazoline derivative and application thereof as antitumor drug | 沈阳工业大学 | 2020-08-07 | — | — | CN | disclosed |