Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.73 |
| ▸ | RET | P07949 | 4/20 | 0.73 |
| ▸ | SRC | P12931 | 4/20 | 0.73 |
| ▸ | FLT4 | P35916 | 3/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.60 |
| ▸ | FLT1 | P17948 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.60 |
| ▸ | KIF5B | P33176 | 1/20 | 0.60 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.60 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 10/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439580 | 0.90 | EGFR (0.71) | KDRRETEPHB2FLT1FGFR1 | |
| SCHEMBL28444206 | 0.89 | EGFR (0.71) | KDRRETEPHB2FLT1EGFR | |
| SCHEMBL28438498 | 0.88 | KDR (0.69) | KDRRETSRCFLT4PDGFRB | |
| SCHEMBL29428187 | 0.88 | KDR (0.69) | KDRRETSRCFLT4PDGFRB | |
| SCHEMBL5474772 | 0.85 | KDR (1.00) | KDRRETSRCEPHB2FLT1 | |
| SCHEMBL28447259 | 0.85 | KDR (0.67) | KDRRETFLT1EGFRABCG2 | |
| Hydrochloric Acid SCHEMBL5483854 | 0.84 | KDR (0.97) | KDRRETSRCEPHB2FLT1 | |
| SCHEMBL28451851 | 0.81 | KDR (0.73) | KDRRETFLT4EPHB2FLT1 | |
| SCHEMBL31067576 | 0.80 | KDR (1.00) | KDRRETSRCFLT4PDGFRB | |
| SCHEMBL5569012 | 0.79 | EGFR (0.72) | KDRRETSRCEPHB2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499583-B | Quinazoline derivative and application thereof as antitumor drug | 沈阳工业大学 | 2022-02-15 | — | — | CN | disclosed |
| CN-111499583-A | Quinazoline derivative and application thereof as antitumor drug | 沈阳工业大学 | 2020-08-07 | — | — | CN | disclosed |