Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.59 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 6/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL218897 | 0.91 | ESR2 (0.67) | DEGS1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL5581754 | 0.91 | ESR2 (0.67) | DEGS1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL698289 | 0.91 | ESR2 (0.67) | DEGS1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL698472 | 0.91 | ESR2 (0.67) | DEGS1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL2095018 | 0.91 | ESR2 (0.67) | DEGS1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL28542248 | 0.91 | ESR2 (0.67) | DEGS1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL28538819 | 0.91 | ESR2 (0.67) | DEGS1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL699003 | 0.91 | ESR2 (0.67) | DEGS1ESR2ESR1CYP3A4CYP2C9 | |
| SCHEMBL28569320 | 0.91 | ESR2 (0.67) | DEGS1ESR2ESR1CYP3A4CYP2C9 | |
| Formaldehyde SCHEMBL9375068 | 0.89 | ESR2 (0.61) | DEGS1ESR2ACMSDESR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111417668-B | Benzopyrrolo copolycarbonate optical articles, articles formed therefrom, and methods of making the same | 高新特殊工程塑料全球技术有限公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-111417668-A | Benzo [ c ] pyrrolidone copolycarbonate optical articles, articles formed therefrom and methods of making same | 沙特基础工业全球技术有限公司 | 2020-07-14 | — | — | CN | disclosed |