Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL338772 | 0.97 | ALDH1A1 (0.72) | ALDH1A1FKBP5TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL222252 | 0.97 | ALDH1A1 (0.72) | ALDH1A1FKBP5TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL27597334 | 0.97 | ALDH1A1 (0.72) | ALDH1A1FKBP5TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL27834115 | 0.97 | ALDH1A1 (0.72) | ALDH1A1FKBP5TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL1491023 | 0.95 | ALDH1A1 (0.68) | ALDH1A1FKBP5TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28505588 | 0.95 | ALDH1A1 (0.68) | ALDH1A1FKBP5TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL15813921 | 0.95 | ALDH1A1 (0.68) | ALDH1A1FKBP5TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL1327908 | 0.95 | ALDH1A1 (0.68) | ALDH1A1FKBP5TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL12003888 | 0.95 | ALDH1A1 (0.68) | ALDH1A1FKBP5TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28709208 | 0.95 | ALDH1A1 (0.68) | ALDH1A1FKBP5TSHRNAPRTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111548372-A | Metal iridium-carbene complex with photocatalytic performance as well as preparation method and application thereof | 常州工学院 | 2020-08-18 | — | — | CN | claimed |
| CN-111548372-A | Metal iridium-carbene complex with photocatalytic performance as well as preparation method and application thereof | 常州工学院 | 2020-08-18 | — | — | CN | disclosed |
| CN-111548372-A | Metal iridium-carbene complex with photocatalytic performance as well as preparation method and application thereof | 常州工学院 | 2020-08-18 | — | — | CN | disclosed |