Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.62 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134594 | 0.87 | SCN10A (0.60) | SUCNR1SCN10AABL1SCN9A | |
| SCHEMBL4591255 | 0.86 | SCN10A (0.65) | SUCNR1SCN10AABL1SCN9AEPHB4 | |
| SCHEMBL25003803 | 0.83 | SUCNR1 (0.67) | SUCNR1SCN10AABL1SCN9AEPHB4 | |
| SCHEMBL22940136 | 0.82 | SCN10A (0.61) | SUCNR1SCN10AABL1SCN9AEPHB4 | |
| SCHEMBL10247654 | 0.82 | SCN9A (0.64) | SCN9AMCL1 | |
| SCHEMBL31301547 | 0.81 | SCN10A (0.62) | SUCNR1SCN10AABL1SCN9ADHODH | |
| SCHEMBL3129022 | 0.80 | MCL1 (0.67) | SCN9ADHODHKDM4EALOX15TSHR | |
| SCHEMBL30614602 | 0.80 | MCL1 (0.60) | ADORA3KDM4EALOX15TSHRACMSD | |
| SCHEMBL4630405 | 0.80 | MCL1 (0.60) | ADORA3KDM4EALOX15TSHRACMSD | |
| SCHEMBL24518040 | 0.80 | SCN9A (0.55) | SCN9AKDM4EALOX15TSHRACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111440174-B | Pyridine amide compound and preparation method and application thereof | 广州医科大学 | 2021-07-09 | — | — | CN | disclosed |
| CN-111440174-A | Pyridine amide compound and preparation method and application thereof | 广州医科大学 | 2020-07-24 | — | — | CN | disclosed |
| CN-101213186-A | Phenylpyridine derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | CN | disclosed |