Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 15/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18191574 | 0.92 | NR1H4 (0.60) | NR1H4HTTMAPTPOLBHDAC1 | |
| SCHEMBL18191667 | 0.91 | NR1H4 (0.59) | NR1H4HTTMAPTHDAC1HDAC6 | |
| SCHEMBL18191585 | 0.91 | NR1H4 (0.59) | NR1H4HTTMAPTHDAC1HDAC6 | |
| SCHEMBL18198164 | 0.90 | NR1H4 (0.57) | NR1H4HTTMAPTPOLBHDAC1 | |
| SCHEMBL18191670 | 0.90 | NR1H4 (0.57) | NR1H4HTTMAPTPOLBHDAC1 | |
| SCHEMBL21574227 | 0.89 | NR1H4 (0.63) | NR1H4MAPTPOLB | |
| SCHEMBL18191653 | 0.87 | NR1H4 (0.55) | NR1H4HTTMAPTPOLB | |
| SCHEMBL18191651 | 0.87 | NR1H4 (0.55) | NR1H4HTTTP53 | |
| SCHEMBL18191624 | 0.87 | NR1H4 (0.55) | NR1H4HTTMAPTPOLB | |
| SCHEMBL18191622 | 0.86 | NR1H4 (0.60) | NR1H4HTTMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531721-B | Fused tricyclic pyrazole derivatives for modulating farnesoid X receptors | 诺华股份有限公司 | 2020-07-17 | — | — | CN | claimed |
| CN-107531721-B | Fused tricyclic pyrazole derivatives for modulating farnesoid X receptors | 诺华股份有限公司 | 2020-07-17 | — | — | CN | disclosed |