Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.85 |
| ▸ | INSR | P06213 | 8/20 | 0.85 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.76 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.73 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.73 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.73 |
| ▸ | EGFR | P00533 | 2/20 | 0.70 |
| ▸ | IGF1R | P08069 | 2/20 | 0.70 |
| ▸ | CDC7 | O00311 | 1/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.70 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.70 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.70 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.70 |
| ▸ | JAK2 | O60674 | 1/20 | 0.70 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.70 |
| ▸ | PAK4 | O96013 | 1/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28054061 | 0.92 | ALK (0.81) | ALKINSRLRRK2MAPK8MAPK9 | |
| SCHEMBL29435444 | 0.90 | ALK (0.84) | ALKINSRLRRK2MAPK8MAPK9 | |
| SCHEMBL22087543 | 0.90 | ALK (0.84) | ALKINSRLRRK2MAPK8MAPK9 | |
| SCHEMBL12311873 | 0.87 | LRRK2 (1.00) | ALKINSRLRRK2MAPK8MAPK9 | |
| SCHEMBL18650996 | 0.85 | ALK (0.85) | ALKINSRLRRK2MAPK8MAPK9 | |
| SCHEMBL11916449 | 0.85 | ALK (0.84) | ALKINSRLRRK2MAPK8MAPK9 | |
| SCHEMBL2061740 | 0.84 | ALK (0.91) | ALKINSRLRRK2MAPK8MAPK9 | |
| SCHEMBL375436 | 0.84 | MAPK9 (0.86) | ALKINSRLRRK2MAPK8MAPK9 | |
| SCHEMBL2060832 | 0.83 | ALK (0.82) | ALKINSRLRRK2MAPK8MAPK9 | |
| SCHEMBL31174591 | 0.83 | ALK (0.87) | ALKINSRLRRK2MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384694-B | Substituted aminopyrimidine derivative and preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2020-09-04 | — | — | CN | disclosed |