Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.69 |
| ▸ | KDR | P35968 | 3/20 | 0.69 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.69 |
| ▸ | KIT | P10721 | 3/20 | 0.69 |
| ▸ | SRC | P12931 | 3/20 | 0.69 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.69 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.69 |
| ▸ | CIT | O14578 | 2/20 | 0.69 |
| ▸ | GAK | O14976 | 2/20 | 0.69 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.69 |
| ▸ | STK17B | O94768 | 2/20 | 0.69 |
| ▸ | STK10 | O94804 | 2/20 | 0.69 |
| ▸ | ABL1 | P00519 | 2/20 | 0.69 |
| ▸ | LCK | P06239 | 2/20 | 0.69 |
| ▸ | LYN | P07948 | 2/20 | 0.69 |
| ▸ | RET | P07949 | 2/20 | 0.69 |
| ▸ | MET | P08581 | 2/20 | 0.69 |
| ▸ | HCK | P08631 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5675006 | 0.96 | EGFR (0.75) | EGFRERBB2KDREPHB4KIT | |
| SCHEMBL7003295 | 0.91 | EGFR (0.68) | EGFRERBB2KDREPHB4KIT | |
| SCHEMBL28935220 | 0.89 | EGFR (0.92) | EGFRERBB2KDREPHB4KIT | |
| SCHEMBL29577309 | 0.89 | EGFR (0.92) | EGFRERBB2KDREPHB4KIT | |
| SCHEMBL31193424 | 0.89 | EGFR (0.65) | EGFRERBB2KDREPHB4KIT | |
| SCHEMBL3590411 | 0.89 | EGFR (0.71) | EGFRERBB2KDREPHB4KIT | |
| SCHEMBL31193415 | 0.87 | EGFR (0.77) | EGFRERBB2 | |
| SCHEMBL7002698 | 0.87 | EGFR (0.74) | EGFRERBB2KDREPHB4KIT | |
| SCHEMBL7003865 | 0.86 | EGFR (0.70) | EGFRERBB2KDREPHB4KIT | |
| SCHEMBL29087952 | 0.85 | KDR (0.56) | EGFRKDREPHB4SRCLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107556295-B | Quinazoline derivatives and process for their preparation | 正大天晴药业集团股份有限公司 | 2020-09-04 | — | — | CN | disclosed |