SCHEMBL28448451

SCHEMBL28448451

Nc1cccc(-c2ccccc2-c2cccc(N)c2N)c1N

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.58
L3MBTL1 Q9Y468 2/20 0.58
CYP3A4 P08684 4/20 0.50
ALOX15 P16050 2/20 0.50
CASP1 P29466 1/20 0.50
CASP7 P55210 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HSD17B10 Q99714 4/20 0.48
CD44 P16070 1/20 0.48
KEAP1 Q14145 2/20 0.46
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
NFE2L2 Q16236 1/20 0.46
ADORA2A P29274 2/20 0.44
PTPRC P08575 1/20 0.44
TSHR P16473 6/20 0.43
HPGD P15428 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
MAOA P21397 2/20 0.41
MAOB P27338 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1645391 0.97 ALDH1A1 (0.55) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1
SCHEMBL560128 0.94 ALDH1A1 (0.56) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1
SCHEMBL2224609 0.92 ALDH1A1 (0.72) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1
Methane SCHEMBL22720568 0.91 ALDH1A1 (0.53) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1
Hydrochloric Acid SCHEMBL4521251 0.91 ALDH1A1 (0.53) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1
SCHEMBL17709511 0.88 ALDH1A1 (0.62) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1
SCHEMBL3335528 0.88 ALDH1A1 (0.62) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1
SCHEMBL17709513 0.88 ALDH1A1 (0.62) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1
SCHEMBL30181056 0.88 ALDH1A1 (0.62) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1
SCHEMBL1809982 0.84 ALDH1A1 (0.58) ALDH1A1L3MBTL1CYP3A4ALOX15CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111433265-A Heat-treated polyamide amide aerogels 蓝移材料有限公司 2020-07-17 CN disclosed