Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 16/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.51 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14657230 | 0.80 | MAPK8 (0.58) | MAPK8MAPK9MAPK3MAPK1 | |
| SCHEMBL14657231 | 0.80 | MAPK8 (0.58) | MAPK8MAPK9MAPK3MAPK1 | |
| SCHEMBL14657649 | 0.79 | MAPK8 (0.69) | MAPK8MAPK9 | |
| SCHEMBL14657650 | 0.79 | MAPK8 (0.69) | MAPK8MAPK9 | |
| SCHEMBL14657249 | 0.77 | MAPK8 (0.54) | MAPK8MAPK9 | |
| SCHEMBL14657251 | 0.77 | MAPK8 (0.54) | MAPK8MAPK9 | |
| SCHEMBL30873307 | 0.77 | MAPK8 (0.54) | MAPK8MAPK9 | |
| SCHEMBL30873324 | 0.73 | MKNK1 (0.52) | MAPK8MAPK9MAPK3MKNK1MKNK2 | |
| SCHEMBL28386712 | 0.71 | MAPK8 (0.50) | MAPK8MAPK9MAPK3MKNK1MKNK2 | |
| SCHEMBL6886583 | 0.70 | MKNK1 (0.48) | MAPK8MAPK9MAPK3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471021-A | Substituted diaminocarboxamides and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith | 西格诺药品有限公司 | 2020-07-31 | — | — | CN | disclosed |