Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.41 |
| ▸ | INSR | P06213 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28455448 | 0.86 | ALK (0.46) | EGFRALKINSRKCNH2LRRK2 | |
| SCHEMBL28448564 | 0.82 | EGFR (0.44) | EGFRKCNH2IGF1R | |
| SCHEMBL28053863 | 0.81 | ALK (0.66) | EGFRALKINSRKCNH2CYP3A4 | |
| SCHEMBL17059196 | 0.77 | EGFR (0.52) | EGFRALKINSRKCNH2CYP3A4 | |
| SCHEMBL17059199 | 0.76 | EGFR (0.52) | EGFRALKINSRKCNH2CYP3A4 | |
| SCHEMBL29855954 | 0.71 | EGFR (0.54) | EGFRALK | |
| SCHEMBL28053984 | 0.70 | ALK (0.58) | EGFRALKINSRKCNH2CYP3A4 | |
| SCHEMBL18239603 | 0.69 | EGFR (0.74) | EGFRINSRKCNH2IGF1R | |
| SCHEMBL30041502 | 0.69 | EGFR (0.51) | EGFRALKKCNH2 | |
| SCHEMBL14719261 | 0.68 | EGFR (0.74) | EGFRINSRKCNH2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384694-B | Substituted aminopyrimidine derivative and preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2020-09-04 | — | — | CN | disclosed |