SCHEMBL2844865

SCHEMBL2844865

O=C(O)C(Cc1ccccc1)c1cncnc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P4HTM Q9NXG6 1/20 0.59
CPA1 P15085 3/20 0.56
EPHX1 P07099 1/20 0.50
CYP1A2 P05177 1/20 0.48
ALPI P09923 1/20 0.46
PKM P14618 1/20 0.46
PTGS1 P23219 1/20 0.46
XIAP P98170 1/20 0.46
SLC7A5 Q01650 1/20 0.46
HDAC8 Q9BY41 2/20 0.43
CPA3 P15088 2/20 0.43
FOLH1 Q04609 1/20 0.43
CPB1 P15086 1/20 0.43
CPB2 Q96IY4 1/20 0.43
PPARG P37231 2/20 0.42
PPARA Q07869 2/20 0.42
SRR Q9GZT4 2/20 0.42
SLC1A3 P43003 1/20 0.42
SLC1A2 P43004 1/20 0.42
SLC1A1 P43005 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19031875 0.87 KDM4E (0.51) P4HTMCPA1PPARGPPARA
SCHEMBL19031879 0.83 CPA1 (0.43) P4HTMCPA1PPARGPPARA
Hydrochloric Acid SCHEMBL28880680 0.82 P4HTM (0.58) P4HTMCPA1EPHX1CYP1A2PPARG
SCHEMBL67234 0.81 EPHX1 (0.71) P4HTMCPA1EPHX1CYP1A2ALPI
SCHEMBL599399 0.81 EPHX1 (0.71) P4HTMCPA1EPHX1CYP1A2ALPI
SCHEMBL3079795 0.81 EPHX1 (0.71) P4HTMCPA1EPHX1CYP1A2ALPI
Hydrochloric Acid SCHEMBL933353 0.80 EPHX1 (0.69) P4HTMCPA1EPHX1CYP1A2ALPI
SCHEMBL7816162 0.77 CHRM1 (0.61) P4HTMCPA1EPHX1CYP1A2PPARG
SCHEMBL7816160 0.77 CHRM1 (0.61) P4HTMCPA1EPHX1CYP1A2PPARG
SCHEMBL9301828 0.77 CHRM1 (0.64) P4HTMCPA1EPHX1CYP1A2PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3394067-A1 4-AMINO-2-(1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL)-6-OXO-6,7-DIHYDRO-5H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND THE RESPECTIVE (1H-INDAZOL-3-YL) DERIVATIVES AS CGMP MODULATORS FOR TREATING CARDIOVASCULAR DISEASES Merck Sharp & Dohme Corp. (US) 2018-10-31 EP disclosed
WO-2017112617-A1 4-AMINO-2-(1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL)-6-OXO-6,7-DIHYDRO-5H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND THE RESPECTIVE (1H-INDAZOL-3-YL) DERIVATIVES AS CGMP MODULATORS FOR TREATING CARDIOVASCULAR DISEASES MERCK SHARP & DOHME CORP. (US) 2017-06-29 WO disclosed
WO-2010027448-A1 ISOTOPICALLY ENRICHED PYRIMIDIN-5-YL ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS ACTIMIS PHARMACEUTICALS INC. (US) 2010-03-11 WO disclosed