Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | IDH2 | P48735 | 11/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30568813 | 0.96 | USP2 (0.83) | USP2SMN1; SMN2IDH2MAPTLMNA | |
| SCHEMBL3758998 | 0.94 | USP2 (0.87) | USP2SMN1; SMN2IDH2MAPTLMNA | |
| SCHEMBL28455289 | 0.91 | USP2 (0.75) | USP2SMN1; SMN2IDH2MAPTLMNA | |
| SCHEMBL30568872 | 0.91 | USP2 (0.75) | USP2SMN1; SMN2IDH2MAPTLMNA | |
| SCHEMBL28455338 | 0.89 | USP2 (0.75) | USP2SMN1; SMN2IDH2MAPTLMNA | |
| SCHEMBL29345107 | 0.88 | MAPT (0.75) | USP2SMN1; SMN2IDH2MAPTPIK3CA | |
| SCHEMBL28897967 | 0.87 | IDH2 (0.70) | USP2SMN1; SMN2IDH2MAPTPIK3CA | |
| SCHEMBL30568855 | 0.87 | IDH2 (0.70) | USP2SMN1; SMN2IDH2MAPTPIK3CA | |
| SCHEMBL18214294 | 0.85 | USP2 (0.67) | USP2SMN1; SMN2IDH2MAPTLMNA | |
| SCHEMBL29345146 | 0.85 | LMNA (0.94) | SMN1; SMN2MAPTLMNAHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662242-B | Heterocyclic IDH mutant inhibitor, preparation method and application thereof | 中国药科大学 | 2023-10-24 | — | — | CN | disclosed |
| CN-111662242-A | Heterocyclic IDH mutant inhibitor, preparation method and application thereof | 中国药科大学 | 2020-09-15 | — | — | CN | disclosed |