Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dibenzoylmethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28456780 | 0.80 | POLB (0.39) | HPGDALDH1A1RARB | |
| SCHEMBL27609548 | 0.78 | TDP1 (0.47) | CES1HPGDSMN1; SMN2MEN1CYP3A4 | |
| Methylamine SCHEMBL27590925 | 0.76 | TDP1 (0.44) | CES1HPGDSMN1; SMN2MEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL7196260 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL28576118 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL7197651 | 0.75 | — | — | |
| SCHEMBL3214885 | 0.75 | MAPT (0.45) | CES1HPGDSMN1; SMN2MEN1CYP3A4 | |
| Dibenzoylmethane SCHEMBL28976283 | 0.74 | KMT2A (0.55) | CES1HPGDSMN1; SMN2MEN1CYP3A4 | |
| SCHEMBL28396536 | 0.74 | HRH3 (0.32) | — | |
| SCHEMBL20972451 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499777-B | Ultrahigh molecular weight polyethylene catalyst, and preparation method and application thereof | 江苏扬农化工集团有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-111499777-A | Ultrahigh molecular weight polyethylene catalyst, and preparation method and application thereof | 江苏扬农化工集团有限公司 | 2020-08-07 | — | — | CN | disclosed |