Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 8/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 5/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28451599 | 1.00 | PLA2G4B (0.49) | PLA2G4BMAPK1TP53TSHRTRPA1 | |
| SCHEMBL28454073 | 0.92 | PLA2G4B (0.53) | PLA2G4BMAPK1TP53TSHRTRPA1 | |
| SCHEMBL28454072 | 0.92 | PLA2G4B (0.53) | PLA2G4BMAPK1TP53TSHRTRPA1 | |
| SCHEMBL28461596 | 0.89 | PLA2G4B (0.48) | PLA2G4BMAPK1TP53TSHRTRPA1 | |
| SCHEMBL28461594 | 0.89 | PLA2G4B (0.48) | PLA2G4BMAPK1TP53TSHRTRPA1 | |
| SCHEMBL28455017 | 0.83 | MAPK1 (0.51) | PLA2G4BMAPK1TP53TSHRTRPA1 | |
| SCHEMBL28455013 | 0.83 | MAPK1 (0.51) | PLA2G4BMAPK1TP53TSHRTRPA1 | |
| SCHEMBL29201126 | 0.82 | PLA2G4B (0.63) | PLA2G4BMAPK1TP53TSHRRARB | |
| SCHEMBL11184944 | 0.76 | TP53 (0.79) | PLA2G4BTP53TSHRRARBPLA2G4A | |
| SCHEMBL11184941 | 0.76 | TP53 (0.79) | PLA2G4BTP53TSHRRARBPLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109761970-B | Protein targeted degradation chimeric molecule, preparation method and application | 中国药科大学 | 2020-06-09 | — | — | CN | disclosed |