Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28455013 | 1.00 | MAPK1 (0.51) | MAPK1TRPA1NR1H4PLA2G4BRXRA | |
| SCHEMBL8544883 | 0.91 | MAPK1 (0.60) | MAPK1NR1H4PLA2G4BRXRARXRB | |
| SCHEMBL8544888 | 0.91 | MAPK1 (0.60) | MAPK1NR1H4PLA2G4BRXRARXRB | |
| SCHEMBL28461596 | 0.86 | PLA2G4B (0.48) | MAPK1TRPA1NR1H4PLA2G4BRXRA | |
| SCHEMBL28461594 | 0.86 | PLA2G4B (0.48) | MAPK1TRPA1NR1H4PLA2G4BRXRA | |
| SCHEMBL28451602 | 0.83 | PLA2G4B (0.49) | MAPK1TRPA1PLA2G4BRXRARXRB | |
| SCHEMBL28451599 | 0.83 | PLA2G4B (0.49) | MAPK1TRPA1PLA2G4BRXRARXRB | |
| SCHEMBL28454073 | 0.81 | PLA2G4B (0.53) | MAPK1TRPA1PLA2G4BRARBTP53 | |
| SCHEMBL28454072 | 0.81 | PLA2G4B (0.53) | MAPK1TRPA1PLA2G4BRARBTP53 | |
| SCHEMBL834902 | 0.77 | NR1H4 (0.70) | MAPK1NR1H4PLA2G4BRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109761970-B | Protein targeted degradation chimeric molecule, preparation method and application | 中国药科大学 | 2020-06-09 | — | — | CN | disclosed |