Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 10/20 | 0.48 |
| ▸ | BRD4 | O60885 | 8/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRLHR | P49683 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2844739 | 1.00 | CREBBP (0.48) | CREBBPBRD4ENPP2TRPV1BCL2 | |
| SCHEMBL2844743 | 1.00 | CREBBP (0.48) | CREBBPBRD4ENPP2TRPV1BCL2 | |
| SCHEMBL2450620 | 0.87 | IMPDH2 (0.36) | CREBBPBRD4TRPV1BCL2IMPDH2 | |
| SCHEMBL2841302 | 0.85 | CREBBP (0.53) | CREBBPBRD4ENPP2TRPV1SYK | |
| SCHEMBL2447343 | 0.83 | CREBBP (0.51) | CREBBPBRD4TRPV1IMPDH2MTOR | |
| SCHEMBL2450067 | 0.79 | CREBBP (0.50) | CREBBPBRD4TRPV1IMPDH2MTOR | |
| SCHEMBL2449067 | 0.78 | CREBBP (0.61) | CREBBPBRD4SYKJAK3 | |
| SCHEMBL2450613 | 0.75 | CREBBP (0.51) | CREBBPBRD4TRPV1IMPDH2PRLHR | |
| SCHEMBL2449938 | 0.75 | CREBBP (0.50) | CREBBPBRD4ROCK2PRLHR | |
| SCHEMBL2451471 | 0.75 | CYP3A4 (0.34) | ENPP2TRPV1SYKJAK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188101-B2 | Dihydropyridopyrimidines for the treatment of AB-related pathologies | ASTRAZENECA AB (SE) | 2012-05-29 | — | — | US | claimed |
| US-20100130495-A1 | COMPOUNDS 563 | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | claimed |
| US-8188101-B2 | Dihydropyridopyrimidines for the treatment of AB-related pathologies | ASTRAZENECA AB (SE) | 2012-05-29 | — | — | US | disclosed |
| US-8188101-B2 | Dihydropyridopyrimidines for the treatment of AB-related pathologies | ASTRAZENECA AB (SE) | 2012-05-29 | — | — | US | disclosed |
| US-20100130495-A1 | COMPOUNDS 563 | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | disclosed |
| US-20100130495-A1 | COMPOUNDS 563 | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130495-A1 | COMPOUNDS 563 | BACE1, PSEN1, PSEN2 | CREBBP 646/4885BRD4 1537/4885ENPP2 642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.