Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | CALM1 | P0DP23 | 3/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223578 | 0.91 | KDM4E (0.77) | KDM4EATMHTR2AHTR2CHTR2B | |
| SCHEMBL29543507 | 0.91 | KDM4E (0.77) | KDM4EATMHTR2AHTR2CHTR2B | |
| SCHEMBL1251843 | 0.91 | KDM4E (0.77) | KDM4EATMHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL27160305 | 0.90 | KDM4E (0.74) | KDM4EATMHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL29963614 | 0.90 | KDM4E (0.74) | KDM4EATMHTR2AHTR2CHTR2B | |
| SCHEMBL623387 | 0.89 | CALM1 (0.51) | KDM4EATMHTR2AHTR2CHTR2B | |
| SCHEMBL22997885 | 0.87 | MEN1 (0.57) | KDM4EATMCALM1LMNACYP1A2 | |
| SCHEMBL7977582 | 0.87 | MEN1 (0.57) | KDM4EATMCALM1LMNACYP1A2 | |
| SCHEMBL2847122 | 0.87 | BIRC5 (0.54) | KDM4EATMHTR2AHTR2CHTR2B | |
| SCHEMBL12788915 | 0.85 | TSHR (0.69) | KDM4EATMHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111170847-B | Novel method for preparing drotaverine hydrochloride intermediate | 江苏联环药业股份有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-109796351-B | Novel preparation method of drotaverine hydrochloride intermediate | 江苏联环药业股份有限公司 | 2021-08-17 | — | — | CN | claimed |
| CN-111170847-A | Novel method for preparing drotaverine hydrochloride intermediate | 江苏联环药业股份有限公司 | 2020-05-19 | — | — | CN | claimed |
| CN-120908328-A | Method for measuring impurity content in 3, 4-diethoxyphenethylamine by utilizing HPLC | 江苏联环药业股份有限公司 | 2025-11-07 | — | — | CN | disclosed |
| CN-120908328-A | Method for measuring impurity content in 3, 4-diethoxyphenethylamine by utilizing HPLC | 江苏联环药业股份有限公司 | 2025-11-07 | — | — | CN | disclosed |
| CN-115073372-A | Preparation method of drotaverine hydrochloride degradation impurities | 江苏联环药业股份有限公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-111170847-B | Novel method for preparing drotaverine hydrochloride intermediate | 江苏联环药业股份有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-111170847-B | Novel method for preparing drotaverine hydrochloride intermediate | 江苏联环药业股份有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-109796351-B | Novel preparation method of drotaverine hydrochloride intermediate | 江苏联环药业股份有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-109796351-B | Novel preparation method of drotaverine hydrochloride intermediate | 江苏联环药业股份有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-111170847-A | Novel method for preparing drotaverine hydrochloride intermediate | 江苏联环药业股份有限公司 | 2020-05-19 | — | — | CN | disclosed |
| US-5231181-A | PROCESS FOR THE PREPARATION OF (8AS,12AS,13AS)-DECAHYDROISOQUINO ((2,1-G) (1,6)-NAPHTHYRIDIN-8-ONE DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0505183-A2 | Process for the preparation of (8aS,12aS,13aS)-decahydroisoquino[2,1-g][1,6]-naphthyridin-8-one derivatives | SYNTEX (U.S.A.) INC. (US) | 1992-09-23 | — | — | EP | disclosed |
| EP-0351399-A1 | ISOQUINOLINE DERIVATIVES, THEIR MANUFACTURE AND USE | HUHTAMÄKI OY (FI) | 1990-01-24 | — | — | EP | disclosed |
| WO-1988007041-A1 | ISOQUINOLINE DERIVATIVES, THEIR MANUFACTURE AND USE | Huhtamäki Oy (FI) | 1988-09-22 | — | — | WO | disclosed |
| EP-0067711-B1 | NEW 1-BENZYL-3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1986-10-01 | — | — | EP | disclosed |
| US-4442108-A | SPASMOLYTIC, HYPOTENSIVE | LABORATOIRES SOBIO S.A. OF IMMEUBLE PERISUD (FR) | 1984-04-10 | — | — | US | disclosed |
| EP-0067711-A2 | New 1-benzyl-3,4-dihydro-isoquinoline derivative | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1982-12-22 | — | — | EP | disclosed |
| US-4126615-A | RANEY NICKEL CATALYST | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1978-11-21 | — | — | US | disclosed |
| US-4107165-A | ANTICOAGULANTS | ENDO LABORATORIES (US) | 1978-08-15 | — | — | US | disclosed |