Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | YES1 | P07947 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CSK | P41240 | 1/20 | 0.42 |
| ▸ | TEC | P42680 | 1/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22710626 | 0.85 | BTK (0.56) | BTKRIPK2EGFRLCKFYN | |
| SCHEMBL5250649 | 0.84 | TNK2 (0.47) | BTKEGFRLCKFYNLYN | |
| SCHEMBL23847508 | 0.83 | TNK2 (0.48) | BTKEGFRLCKFYNLYN | |
| SCHEMBL21044860 | 0.83 | BTK (0.69) | BTKRIPK2EGFRLCKFYN | |
| SCHEMBL21044818 | 0.83 | BTK (0.69) | BTKRIPK2EGFRLCKFYN | |
| SCHEMBL11959218 | 0.83 | BTK (0.69) | BTKRIPK2EGFRLCKFYN | |
| SCHEMBL21044817 | 0.80 | BTK (0.53) | BTKTEC | |
| SCHEMBL28231422 | 0.79 | BTK (0.49) | BTKTEC | |
| SCHEMBL23834462 | 0.79 | BTK (0.45) | BTKLCKTEC | |
| SCHEMBL19230428 | 0.78 | BTK (0.56) | BTKLCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109851620-B | Fused bicyclic compounds for inhibiting tyrosine kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2020-08-07 | — | — | CN | disclosed |