Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 16/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | APP | P05067 | 1/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30568804 | 1.00 | IDH2 (1.00) | IDH2MAPTAPPLRRK2USP2 | |
| SCHEMBL28450644 | 0.93 | IDH2 (1.00) | IDH2MAPTAPPLRRK2 | |
| SCHEMBL30568844 | 0.93 | IDH2 (1.00) | IDH2MAPTAPPLRRK2 | |
| SCHEMBL30568821 | 0.93 | IDH2 (1.00) | IDH2MAPTAPPLRRK2 | |
| SCHEMBL30568848 | 0.93 | IDH2 (1.00) | IDH2MAPTAPPLRRK2 | |
| SCHEMBL28450649 | 0.93 | IDH2 (1.00) | IDH2MAPTAPPLRRK2 | |
| SCHEMBL28460705 | 0.93 | IDH2 (1.00) | IDH2MAPTAPPLRRK2 | |
| SCHEMBL28455243 | 0.89 | IDH2 (0.92) | IDH2MAPTAPP | |
| SCHEMBL30568831 | 0.88 | IDH2 (0.90) | IDH2MAPTAPPLRRK2 | |
| SCHEMBL30568805 | 0.88 | IDH2 (1.00) | IDH2MAPTAPPUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662242-A | Heterocyclic IDH mutant inhibitor, preparation method and application thereof | 中国药科大学 | 2020-09-15 | — | — | CN | disclosed |