Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | FPR2 | P25090 | 4/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29042019 | 0.91 | USP30 (0.47) | USP30FPR2BACE1GPR119ABL1 | |
| SCHEMBL29042052 | 0.91 | USP30 (0.47) | USP30FPR2BACE1GPR119ABL1 | |
| SCHEMBL28457723 | 0.91 | USP30 (0.44) | USP30FPR2BACE1RORCKCNK3 | |
| SCHEMBL28463632 | 0.90 | FPR2 (0.48) | USP30FPR2BACE1FPR3JAK1 | |
| SCHEMBL20135633 | 0.89 | FPR2 (0.45) | USP30FPR2BACE1GPR119 | |
| SCHEMBL25335635 | 0.83 | USP30 (0.43) | USP30FPR2BACE1RORCKCNK3 | |
| SCHEMBL25958972 | 0.83 | USP30 (0.43) | USP30FPR2BACE1RORCKCNK3 | |
| SCHEMBL25335630 | 0.83 | USP30 (0.43) | USP30FPR2BACE1RORCKCNK3 | |
| SCHEMBL26654669 | 0.81 | EHMT2 (0.43) | PDE4B | |
| SCHEMBL28456256 | 0.81 | FPR2 (0.48) | USP30FPR2BACE1FPR3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117986262-A | Condensed bicyclic compounds, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-111662232-B | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-08-02 | — | — | CN | disclosed |
| CN-111662232-A | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2020-09-15 | — | — | CN | disclosed |