Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | FPR3 | P25089 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3697678 | 0.81 | USP30 (0.44) | USP30CA1CA2CCNE1CDK2 | |
| SCHEMBL31418598 | 0.77 | USP30 (0.41) | USP30AAK1CA1CA2LCK | |
| SCHEMBL31418506 | 0.77 | USP30 (0.41) | USP30AAK1CA1CA2LCK | |
| SCHEMBL31512022 | 0.77 | USP30 (0.44) | USP30AAK1CA1LCKPRMT5 | |
| SCHEMBL35210589 | 0.76 | USP30 (0.43) | USP30AAK1CA1CA2LCK | |
| SCHEMBL1367326 | 0.76 | USP30 (0.77) | USP30AAK1PRMT5WDR77DGAT1 | |
| SCHEMBL640631 | 0.76 | FFAR2 (0.52) | CA1CA2LCKCCNB2CCNE2 | |
| SCHEMBL13266901 | 0.76 | CA1 (0.47) | CA1CA2LCKCCNB2CCNE2 | |
| SCHEMBL1180976 | 0.75 | AAK1 (0.47) | USP30AAK1PRMT5WDR77DGAT1 | |
| SCHEMBL31167785 | 0.75 | LCK (0.42) | USP30AAK1LCKPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699035-B | Novel compounds | 特殊治疗有限公司 | 2021-10-15 | — | — | CN | disclosed |
| CN-108290872-B | Cyanopyrrolidine derivatives as DUBs inhibitors | 特殊治疗有限公司 | 2020-10-02 | — | — | CN | disclosed |