Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.65 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29437342 | 0.87 | BRD4 (0.71) | BRD4RORCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL17992510 | 0.79 | BRD4 (1.00) | BRD4RORCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29353577 | 0.79 | MEN1 (0.60) | BRD4ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9450622 | 0.78 | BRD4 (0.53) | BRD4ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL17982444 | 0.78 | CYP1B1 (0.59) | BRD4ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL24158402 | 0.78 | CYP1B1 (0.59) | BRD4ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL17982449 | 0.77 | CDC25A (0.58) | BRD4ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL17992517 | 0.76 | BRD4 (0.87) | BRD4RORCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29437335 | 0.76 | BRD4 (0.87) | BRD4RORCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20864359 | 0.76 | BRD4 (0.54) | BRD4ALDH1A1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662226-A | 2-oxo-1, 2-dihydrobenzo [ cd ] indole compound | 中国科学院广州生物医药与健康研究院 | 2020-09-15 | — | — | CN | claimed |
| CN-111662226-B | 2-oxo-1, 2-dihydrobenzo [ cd ] indole compound | 中国科学院广州生物医药与健康研究院 | 2022-03-18 | — | — | CN | disclosed |
| CN-105985282-B | 2-oxo-1, 2-dihydrobenzo [ cd ] indole compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2020-12-08 | — | — | CN | disclosed |
| CN-111662226-A | 2-oxo-1, 2-dihydrobenzo [ cd ] indole compound | 中国科学院广州生物医药与健康研究院 | 2020-09-15 | — | — | CN | disclosed |