Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | THRB | P10828 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | RECQL | P46063 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | PRMT1 | Q99873 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12146319 | 0.98 | MEN1 (0.67) | MEN1KMT2ATDP1LMNAMAPT | |
| SCHEMBL29767729 | 0.98 | MEN1 (0.67) | MEN1KMT2ATDP1LMNAMAPT | |
| Bromide SCHEMBL31674744 | 0.97 | MEN1 (0.65) | MEN1KMT2ATDP1LMNAMAPT | |
| Iodide SCHEMBL26979236 | 0.85 | MEN1 (0.58) | MEN1KMT2ATDP1LMNAMAPT | |
| SCHEMBL12364558 | 0.84 | MEN1 (0.60) | MEN1KMT2ATDP1LMNAMAPT | |
| Iodide SCHEMBL21192749 | 0.83 | HTT (0.56) | MEN1KMT2ATDP1LMNAMAPT | |
| Iodide SCHEMBL22542616 | 0.83 | HTT (0.56) | MEN1KMT2ATDP1LMNAMAPT | |
| Iodide SCHEMBL22614761 | 0.83 | HTT (0.56) | MEN1KMT2ATDP1LMNAMAPT | |
| SCHEMBL13592434 | 0.83 | MEN1 (0.63) | MEN1KMT2ATDP1LMNAMAPT | |
| SCHEMBL25592207 | 0.83 | KMT2A (0.63) | MEN1KMT2ATDP1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393807-A1 | PHOTOACOUSTIC VOLTAGE-SENSITIVE DYES FOR IN VIVO IMAGING | UNIVERSITY OF CONNECTICUT | 2021-12-23 | — | — | US | disclosed |
| US-10808128-B2 | Compounds as fluorescent probes, synthesis and applications thereof | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (INSTEM) (IN) | 2020-10-20 | — | — | US | disclosed |
| US-20180200389-A1 | PHOTOACOUSTIC VOLTAGE-SENSITIVE DYES FOR IN VIVO IMAGING | THE JOHNS HOPKINS UNIVERSITY | 2018-07-19 | — | — | US | disclosed |
| US-20100129293-A1 | Near Infrared Imaging Agent | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAT BERLIN (DE) | 2010-05-27 | — | — | US | disclosed |
| US-7655217-B2 | Near infrared imaging agent | Institut fur Diagnosikforschung GmbH (DE) | 2010-02-02 | — | — | US | disclosed |
| US-7445767-B2 | In-vivo diagnostic method by near infrared radiation | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAT BERLIN (DE) | 2008-11-04 | — | — | US | disclosed |
| US-20060165599-A1 | Near infrared imaging agent | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH (DE) | 2006-07-27 | — | — | US | disclosed |
| US-20060165598-A1 | In-vivo diagnostic method by near infrared radiation | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAT BERLIN (DE) | 2006-07-27 | — | — | US | disclosed |
| US-7025949-B2 | In-vivo diagnostic method by means of near infrared radiation | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAT BERLIN (DE) | 2006-04-11 | — | — | US | disclosed |
| US-6926885-B2 | In-vivo diagnostic method by means of near infrared radiation | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH (DE) | 2005-08-09 | — | — | US | disclosed |
| US-20050106106-A1 | In-vivo diagnostic method by near infrared radiation | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAT BERLIN (DE) | 2005-05-19 | — | — | US | disclosed |
| EP-1104761-B1 | FLUORESCENT LABELLING REAGENTS | DAIICHI PURE CHEMICALS CO LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| US-20030170179-A1 | Near infrared imaging agent | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITA (COPY) | 2003-09-11 | — | — | US | disclosed |
| US-20030026763-A1 | In-vivo diagnostic method by means of near infrared radiation | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAT BERLIN | 2003-02-06 | — | — | US | disclosed |
| US-6403625-B1 | 2(7-(1,3-DIHYDRO-1,1-DIMETHYL-3-ETHYLBENZ(E)INDOLIN-2-YLIDENE) -1,3,5-HEPTATRIENYL)-1,1-DIMETHYL-3-((6-((1,3-THIAZOLIDINE-2-T HION)-1-YL)-6-OXO)HEXYL)-1H-BENZ(E)INDOLIUM CHLORIDE; STAINS PROTEINS FOR CANCER IDENTIFICATION | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1181940-A2 | In vivo diagnostics by near infrared radiation | INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN (DE) | 2002-02-27 | — | — | EP | disclosed |
| US-20010055567-A1 | In-vivo diagnostic method by means of near infrared radiation | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITAT BERLIN | 2001-12-27 | — | — | US | disclosed |
| US-6258340-B1 | USING WATER-SOLUBLE DYES AND THEIR BIOMOLECULE ADDUCTS EACH HAVING SPECIFIC PHOTOPHYSICAL AND PHARMOCHEMICAL PROPERTIES | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH (DE) | 2001-07-10 | — | — | US | disclosed |
| EP-1104761-A1 | FLUORESCENT LABELLING REAGENTS | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2001-06-06 | — | — | EP | disclosed |
| US-6083485-A | USEING WATER-SOLUBLE DYES AND THEIR BIOMOLECULE ADDUCTS AS CONTRAST MEDIUM FOR FLUORESCENCE AND TRANSILLUMINATION DIAGNOSTICS IN THE NEAR INFRARED RADIATION RANGE | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH (DE) | 2000-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060165598-A1 | In-vivo diagnostic method by near infrared radiation | GUSB, CYBA, ABCG2 | MEN1 2301/4885KMT2A 4813/4885TDP1 1214/4885 |
| US-20100129293-A1 | Near Infrared Imaging Agent | UGT1A10, ABCG2, SLCO1B1 | MEN1 2145/4885KMT2A 4699/4885TDP1 1510/4885 |
| US-20210393807-A1 | PHOTOACOUSTIC VOLTAGE-SENSITIVE DYES FOR IN VIVO IMAGING | KCNN2, KCNN1, KCNN3 | MEN1 2750/4885KMT2A 3916/4885TDP1 2161/4885 |
| US-20050106106-A1 | In-vivo diagnostic method by near infrared radiation | GUSB, CYBA, ABCG2 | MEN1 2301/4885KMT2A 4813/4885TDP1 1214/4885 |
| US-20180200389-A1 | PHOTOACOUSTIC VOLTAGE-SENSITIVE DYES FOR IN VIVO IMAGING | KCNN2, KCNN1, KCNN3 | MEN1 2750/4885KMT2A 3916/4885TDP1 2161/4885 |
| US-20060165599-A1 | Near infrared imaging agent | UGT1A10, ABCG2, SLCO1B1 | MEN1 2145/4885KMT2A 4699/4885TDP1 1510/4885 |
| US-20010055567-A1 | In-vivo diagnostic method by means of near infrared radiation | GUSB, ABCG2, SLCO1B1 | MEN1 2339/4885KMT2A 4842/4885TDP1 1497/4885 |
| US-20030026763-A1 | In-vivo diagnostic method by means of near infrared radiation | GUSB, ABCG2, SLCO1B1 | MEN1 2339/4885KMT2A 4842/4885TDP1 1497/4885 |
| US-20030170179-A1 | Near infrared imaging agent | UGT1A10, ABCG2, SLCO1B1 | MEN1 2145/4885KMT2A 4699/4885TDP1 1510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.