Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.68 |
| ▸ | JAK2 | O60674 | 13/20 | 0.68 |
| ▸ | JAK3 | P52333 | 6/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28458754 | 0.86 | JAK1 (0.56) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL21400612 | 0.84 | JAK2 (0.71) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL28466426 | 0.83 | JAK1 (0.62) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL20183394 | 0.81 | JAK1 (1.00) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL20183389 | 0.81 | JAK1 (1.00) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL21400284 | 0.81 | JAK1 (0.76) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL21400276 | 0.81 | JAK1 (0.76) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL28465851 | 0.80 | PAK1 (0.76) | JAK1JAK2JAK3BTK | |
| SCHEMBL21400293 | 0.79 | JAK1 (0.60) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL21400286 | 0.79 | JAK1 (0.71) | JAK1JAK2JAK3TYK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111620873-A | Pyrrolo [2,3-d ] pyrimidine derivatives containing piperidine and preparation and application thereof | 沈阳药科大学 | 2020-09-04 | — | — | CN | claimed |
| CN-111620873-B | Pyrrolo [2,3-d ] pyrimidine derivatives containing piperidine and preparation and application thereof | 沈阳药科大学 | 2021-12-28 | — | — | CN | disclosed |
| CN-111620873-A | Pyrrolo [2,3-d ] pyrimidine derivatives containing piperidine and preparation and application thereof | 沈阳药科大学 | 2020-09-04 | — | — | CN | disclosed |