Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.35 |
| ▸ | IDO1 | P14902 | 6/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | LDLR | P01130 | 1/20 | 0.31 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20225762 | 0.75 | FYN (0.32) | IDO1CYP11B1CYP11B2 | |
| SCHEMBL19732321 | 0.73 | IDO1 (0.57) | NUDT1P2RX7IDO1CYP11B1CYP11B2 | |
| SCHEMBL1484285 | 0.73 | GAA (0.36) | IDO1CYP11B1CYP11B2HSP90AA1HSP90AB1 | |
| SCHEMBL4806085 | 0.73 | CYP11B1 (0.43) | P2RX7CYP11B1CYP11B2HSP90AA1LMNA | |
| SCHEMBL1482948 | 0.72 | KMT2A (0.37) | LMNAALDH1A1 | |
| SCHEMBL1638486 | 0.72 | CYP19A1 (0.37) | CYP11B1CYP11B2LMNAALDH1A1 | |
| SCHEMBL2205776 | 0.72 | CYP19A1 (0.32) | CYP11B1CYP11B2LMNA | |
| SCHEMBL20225761 | 0.71 | NPC1 (0.36) | IDO1LMNALCKALDH1A1 | |
| SCHEMBL1639289 | 0.70 | CYP46A1 (0.36) | CYP11B1CYP11B2LMNALCKSRC | |
| SCHEMBL1482976 | 0.69 | GAA (0.35) | IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107879979-B | Preparation method of dexmedetomidine | 广东莱佛士制药技术有限公司 | 2020-08-25 | — | — | CN | claimed |
| CN-107879979-B | Preparation method of dexmedetomidine | 广东莱佛士制药技术有限公司 | 2020-08-25 | — | — | CN | disclosed |
| CN-107879979-B | Preparation method of dexmedetomidine | 广东莱佛士制药技术有限公司 | 2020-08-25 | — | — | CN | disclosed |