SCHEMBL2846251

SCHEMBL2846251

CC(C)(C)c1ccc(P(O)F)c(C(C)(C)C)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
ALOX15 P16050 2/20 0.41
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MAPT P10636 4/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
GAA P10253 1/20 0.37
PKM P14618 1/20 0.37
RECQL P46063 1/20 0.37
LMNA P02545 1/20 0.35
TYR P14679 1/20 0.35
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
KIF11 P52732 2/20 0.33
ACLY P53396 1/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
ACHE P22303 3/20 0.33
NPC1 O15118 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28432207 0.84 ALDH1A1 (0.43) ALDH1A1ALOX15HPGDHSD17B10TDP1
SCHEMBL29216516 0.83 ALDH1A1 (0.39) ALDH1A1ALOX15HPGDHSD17B10TDP1
SCHEMBL2465881 0.79 ALDH1A1 (0.41) ALDH1A1ALOX15HPGDHSD17B10TDP1
SCHEMBL29762702 0.79 ALDH1A1 (0.41) ALDH1A1ALOX15HPGDHSD17B10TDP1
SCHEMBL28355573 0.77 ALDH1A1 (0.55) ALDH1A1ALOX15HPGDHSD17B10TDP1
SCHEMBL28138897 0.76 ALDH1A1 (0.39) ALDH1A1ALOX15HPGDHSD17B10TDP1
SCHEMBL9347288 0.76 ALDH1A1 (0.39) ALDH1A1ALOX15HPGDHSD17B10TDP1
SCHEMBL28228251 0.75 TSHR (0.37) ALDH1A1ALOX15HPGDHSD17B10TDP1
SCHEMBL31222192 0.74 CYP1A2 (0.40) ALDH1A1ALOX15HPGDHSD17B10TDP1
SCHEMBL1705525 0.73 APEX1 (0.38) ALDH1A1ALOX15HPGDHSD17B10TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0651006-B1 Piperidinyl phosphite compositions and polyolefin compositions containing them MONTELL NORTH AMERICA INC (US) 1998-03-11 EP claimed
US-8975333-B2 Method for improving flowability of random polypropylene powder BOREALIS AG (AT) 2015-03-10 US disclosed
US-8404148-B2 Composition with a polymer and an oxidation-catalyst DSM IP ASSETS B.V. (NL) 2013-03-26 US disclosed
US-20110294937-A1 METHOD FOR IMPROVING FLOWABILITY OF RANDOM POLYPROPYLENE POWDER BOREALIS AG (AT) 2011-12-01 US disclosed
US-20100130695-A1 COMPOSITION WITH A POLYMER AND AN OXIDATION-CATALYST DSM IP ASSETS B.V. (NL) 2010-05-27 US disclosed
US-20100051860-A1 COMPOSITION WITH A POLYMER AND AN OXIDATION-CATALYST DSM IP ASSETS B.V. (NL) 2010-03-04 US disclosed
WO-2008033659-A1 POLYUREAURETHANE COMPOSITION HAVING IMPROVED COLOR STABILITY PPG INDUSTRIES OHIO, INC. (US) 2008-03-20 WO disclosed
US-5747162-A SUBSTRATE WITH DRIED RESIDUE OF CURABLE COMPOSITION CONTAINING TERPENE AND/OR VITAMIN ANTIOXIDANT, FILM FORMING MATERIAL PPG INDUSTRIES, INC. (US) 1998-05-05 US disclosed