Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL933722 | 0.89 | — | — | |
| Ethylenediamine SCHEMBL28900843 | 0.75 | LMNA (0.33) | TP53MEN1CYP1A2KMT2ALMNA | |
| SCHEMBL4916947 | 0.75 | LMNA (0.33) | TP53LMNA | |
| SCHEMBL8941483 | 0.74 | — | — | |
| SCHEMBL3488846 | 0.74 | — | — | |
| SCHEMBL28122290 | 0.72 | MEN1 (0.32) | TP53MEN1CYP1A2KMT2ACA1 | |
| SCHEMBL11506493 | 0.71 | — | — | |
| SCHEMBL21708252 | 0.70 | — | — | |
| SCHEMBL27628767 | 0.70 | MEN1 (0.33) | TP53MEN1CYP1A2KMT2ALMNA | |
| SCHEMBL10524121 | 0.69 | CA1 (0.44) | TP53BLMCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478973-A | Aqueous polyurethane resin and preparation method thereof | 南亚塑胶工业股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-111808238-A | Preparation method of aqueous polyurethane dispersion liquid | 南亚塑胶工业股份有限公司 | 2020-10-23 | — | — | CN | disclosed |