Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26488892 | 0.98 | FNTA (0.48) | FNTAFNTBFDPSSMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL28457259 | 0.97 | FNTA (0.47) | FNTAFNTBFDPSSMN1; SMN2KMT2A | |
| SCHEMBL5541391 | 0.93 | FNTA (0.47) | FNTAFNTBFDPSSMN1; SMN2KMT2A | |
| Sulfuric Acid SCHEMBL28454243 | 0.92 | FNTA (0.45) | FNTAFNTBFDPSSMN1; SMN2KMT2A | |
| SCHEMBL5535092 | 0.92 | TBXAS1 (0.46) | FNTAFNTBFDPSSMN1; SMN2KMT2A | |
| SCHEMBL5533480 | 0.92 | TBXAS1 (0.46) | FNTAFNTBFDPSSMN1; SMN2KMT2A | |
| SCHEMBL5538455 | 0.92 | TBXAS1 (0.46) | FNTAFNTBFDPSSMN1; SMN2KMT2A | |
| SCHEMBL5535723 | 0.92 | TBXAS1 (0.46) | FNTAFNTBFDPSSMN1; SMN2KMT2A | |
| SCHEMBL5538890 | 0.92 | TBXAS1 (0.46) | FNTAFNTBFDPSSMN1; SMN2KMT2A | |
| SCHEMBL5546300 | 0.92 | TBXAS1 (0.46) | FNTAFNTBFDPSSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110041533-B | Method for preparing functionalized metal organic framework material by ionic liquid ligand displacement method | 福州大学 | 2020-08-11 | — | — | CN | claimed |
| CN-110041533-B | Method for preparing functionalized metal organic framework material by ionic liquid ligand displacement method | 福州大学 | 2020-08-11 | — | — | CN | disclosed |