Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 15/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 2/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28455858 | 0.90 | FBP1 (0.69) | FBP1MEN1KMT2AMAPTCRHBP | |
| SCHEMBL28469977 | 0.86 | FBP1 (0.66) | FBP1 | |
| SCHEMBL28461385 | 0.85 | FBP1 (0.62) | FBP1KMT2AMAPTCRHBPCRHR2 | |
| SCHEMBL28469953 | 0.84 | FBP1 (0.62) | FBP1KMT2AHTTMAPTNPC1 | |
| SCHEMBL28463835 | 0.83 | FBP1 (0.64) | FBP1MAPTCRHBPCRHR2NPC1 | |
| SCHEMBL28469967 | 0.82 | FBP1 (0.53) | FBP1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL28467678 | 0.82 | FBP1 (0.67) | FBP1 | |
| SCHEMBL28457753 | 0.81 | FBP1 (0.52) | FBP1 | |
| SCHEMBL28461240 | 0.81 | FBP1 (0.65) | FBP1MAPTCRHBPCRHR2NPC1 | |
| SCHEMBL28467759 | 0.80 | FBP1 (0.66) | FBP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107098846-B | N-acyl sulfonamide FBPase inhibitor, preparation method thereof, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-10-09 | — | — | CN | disclosed |