Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29560480 | 1.00 | JAK2 (0.43) | JAK2SUV39H2MEN1KMT2AMMP8 | |
| SCHEMBL29560115 | 0.92 | MEN1 (0.45) | SUV39H2MEN1KMT2ACA2 | |
| SCHEMBL31045300 | 0.87 | JAK2 (0.44) | JAK2SUV39H2MEN1KMT2AMMP8 | |
| SCHEMBL31045429 | 0.86 | JAK2 (0.43) | JAK2SUV39H2MEN1KMT2AMMP8 | |
| SCHEMBL22690412 | 0.85 | MMP8 (0.44) | JAK2SUV39H2MEN1KMT2AMMP8 | |
| SCHEMBL22690408 | 0.85 | MMP8 (0.44) | JAK2SUV39H2MEN1KMT2AMMP8 | |
| SCHEMBL29560688 | 0.84 | JAK2 (0.41) | JAK2SUV39H2MEN1KMT2AMMP8 | |
| SCHEMBL18245320 | 0.83 | MAPT (0.42) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL25291368 | 0.82 | RAD51 (0.45) | JAK2SUV39H2MEN1KMT2AMMP8 | |
| SCHEMBL22690914 | 0.82 | RAD51 (0.45) | JAK2SUV39H2MEN1KMT2AMMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111620861-A | BCL-XL inhibitory compound having low cell permeability and antibody drug conjugate including the same | 艾伯维公司 | 2020-09-04 | — | — | CN | disclosed |