Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.59 |
| ▸ | BAZ2B | Q9UIF8 | 5/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21114812 | 0.87 | HTR6 (0.56) | HTR6BAZ2BPTGS1PTGS2LMNA | |
| SCHEMBL28464449 | 0.84 | HTR6 (0.53) | HTR6LMNAPSEN1PSEN2APH1B | |
| SCHEMBL3475930 | 0.82 | HTR6 (0.50) | HTR6BAZ2BPTGDR2PSEN1PSEN2 | |
| SCHEMBL12868529 | 0.77 | HTR6 (0.78) | HTR6 | |
| SCHEMBL1005802 | 0.76 | HTR6 (0.46) | HTR6BAZ2BPTGS1PTGS2PSEN1 | |
| SCHEMBL26794690 | 0.74 | HTR6 (0.58) | HTR6PTGDR2 | |
| SCHEMBL1005636 | 0.74 | HTR6 (0.47) | HTR6BAZ2BPSEN1PSEN2APH1B | |
| SCHEMBL834193 | 0.74 | HTR6 (1.00) | HTR6 | |
| SCHEMBL3478091 | 0.73 | HTR6 (0.45) | HTR6BAZ2BPSEN1PSEN2APH1B | |
| SCHEMBL801286 | 0.73 | HTR6 (1.00) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111757882-A | 1,3,4, 5-tetrahydro-2H-pyrido [4,3-b ] indole derivatives for the treatment, alleviation or prevention of disorders associated with Tau aggregates such as alzheimer's disease | AC免疫有限公司 | 2020-10-09 | — | — | CN | disclosed |