Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 7/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 8/20 | 0.57 |
| ▸ | MET | P08581 | 3/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | TEK | Q02763 | 2/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | LYN | P07948 | 1/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30448190 | 1.00 | PDGFRA (0.62) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL28473963 | 0.88 | KDR (0.62) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL28464542 | 0.88 | PDGFRA (0.60) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL30447731 | 0.88 | KDR (0.62) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL30447786 | 0.86 | PDGFRA (0.56) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL28476037 | 0.86 | PDGFRA (0.56) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL28470533 | 0.83 | KDR (0.63) | PDGFRAKDRMETAURKALCK | |
| SCHEMBL4470477 | 0.80 | PDGFRA (0.74) | PDGFRAPDGFRBKDRFGFR2 | |
| SCHEMBL2747381 | 0.80 | KDR (0.67) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL14967325 | 0.80 | PDGFRA (0.74) | PDGFRAPDGFRBKDRMETAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825605-B | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-03-31 | — | — | CN | disclosed |
| CN-111825605-A | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2020-10-27 | — | — | CN | disclosed |