Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.57 |
| ▸ | FLT4 | P35916 | 5/20 | 0.57 |
| ▸ | CSF1R | P07333 | 4/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | KIF5B | P33176 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30448369 | 1.00 | KDR (0.69) | KDRPDGFRAPDGFRBFLT4CSF1R | |
| SCHEMBL28475707 | 0.85 | KDR (0.62) | KDRPDGFRAFLT4CSF1RRAF1 | |
| SCHEMBL30447427 | 0.85 | KDR (0.62) | KDRPDGFRAFLT4CSF1RRAF1 | |
| SCHEMBL30447769 | 0.85 | KDR (0.66) | KDRPDGFRAPDGFRBFLT4CSF1R | |
| SCHEMBL28468402 | 0.85 | KDR (0.66) | KDRPDGFRAPDGFRBFLT4CSF1R | |
| SCHEMBL30448215 | 0.85 | KDR (0.66) | KDRPDGFRAFLT4CSF1RRAF1 | |
| SCHEMBL28979437 | 0.85 | KDR (0.66) | KDRPDGFRAFLT4CSF1RRAF1 | |
| SCHEMBL30448125 | 0.84 | KDR (0.65) | KDRPDGFRAPDGFRBFLT4CSF1R | |
| SCHEMBL28979421 | 0.84 | KDR (0.65) | KDRPDGFRAPDGFRBFLT4CSF1R | |
| SCHEMBL30448543 | 0.83 | KDR (0.61) | KDRPDGFRAPDGFRBFLT4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825605-B | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-03-31 | — | — | CN | disclosed |
| CN-111825605-A | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2020-10-27 | — | — | CN | disclosed |