SCHEMBL28464631

SCHEMBL28464631

O=C(Cl)c1cccc2cc3ccccc3nc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
ALDH1A1 P00352 7/20 0.47
HPGD P15428 3/20 0.47
GLA P06280 1/20 0.47
MAPT P10636 1/20 0.47
ACHE P22303 1/20 0.47
IKBKB O14920 1/20 0.44
AOX1 Q06278 1/20 0.41
KDM4E B2RXH2 3/20 0.41
GAA P10253 2/20 0.41
STAT3 P40763 1/20 0.41
ALOX15 P16050 1/20 0.40
PTPRA P18433 1/20 0.38
KDR P35968 1/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
CNR2 P34972 1/20 0.38
PARP1 P09874 1/20 0.38
MGAM O43451 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL902623 0.84 ALDH1A1 (0.66) HDAC1HDAC6ALDH1A1HPGDGLA
SCHEMBL30661004 0.83 IKBKB (0.60) HDAC1HDAC6ALDH1A1HPGDGLA
SCHEMBL461849 0.83 IKBKB (0.60) HDAC1HDAC6ALDH1A1HPGDGLA
SCHEMBL27448248 0.82 HDAC1 (0.46) HDAC1HDAC6ALDH1A1HPGDGLA
Hydrochloric Acid SCHEMBL31161184 0.81 IKBKB (0.58) HDAC1HDAC6ALDH1A1HPGDGLA
SCHEMBL28276351 0.81 IKBKB (0.58) HDAC1HDAC6ALDH1A1HPGDGLA
SCHEMBL28383030 0.80 ALDH1A1 (0.70) ALDH1A1GLAMAPTACHEKDM4E
SCHEMBL10525572 0.80 HDAC1 (0.63) HDAC1HDAC6ALDH1A1HPGDGLA
SCHEMBL3535241 0.79 ALDH1A1 (0.51) ALDH1A1HPGDGLAMAPTACHE
SCHEMBL7030506 0.79 KDM4E (0.56) HDAC1HDAC6ALDH1A1HPGDAOX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-211586555-U Reaction kettle for preparing acyl chloride compounds 长春百纯和成医药科技有限公司 2020-09-29 CN disclosed